Jul 20, 2023

Search sequence databases for structural RNA homologs

Infernal, standing for “INFERence of RNA ALignment”, is a tool for searching DNA sequence database for RNA structure and sequence similarities.

It is based on Covariance Model CM, which scores a combination of sequence consensus and RNA secondary structure consensus, and thus is more capable of identifying RNA homologs than using primary sequence profile.

The Rfam database of RNA families is based on Infernal.

Citation Nawrocki & Eddy 2013 Infernal 1.1 100-fold faster RNA homology searches, Bioinformatics 29 2933-2935.

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